Group leader: Hans V. Westerhoff

Group name: Molecular Cell Physiology and Mathematical Biochemistry

Other staff members involved: Barbara Bakker (yeast, trypanosomes), Fred Boogerd (emergence), Klaas Krab (diabetes, modular kinetic analyses), Wilfred Roling (microbial ecology), Jacky L. Snoep (als US, South Africa; Silicon cell), Rob van Spanning (Paracoccus, gene networks and rgeulation), Henk van Verseveld (microbial ecology)

Location: Centre for Research on BioComplex Systems, BCA, Free University and Swammerdam Institute for Life Sciences, BCA, University of Amsterdam

Web page: http://www.bio.vu.nl/html/cell_phy.html and <http://www.bio.vu.nl/hwconf>

E-Mail: hw@bio.vu.nl

Phone: +31 20 4447230 (+31 20 4447229 fax)

Relevant research interests:

- System Biology: How through multiple interactions macromolecules generate the functional behavior of living cells

- Entering the living cell, i.e. perform quantitative experiments to determine the behavior of macromolecules in living cells

- Principles of control, regulation and non equilibrium thermodynamics and statistical mechanics

- Silicon cell, i.e. computer replica of parts of living cells

- Network-based drug design

- Ecological control analysis, i.e. 3exmaine whether control and regulation properties of intracellular pathways also operate in ecosystems

- Integrative and vertical genomics: How genome, transcriptome, proteome, metabolome and physiome together and not individually lead to functioning genomics.

- Integrative bioinformatics

- Tumor system biology

Current system biology activities:

Cellular Bioinformatics, (including Theoretical Biochemistry, Computational biochemistry, and Mathematical Biochemistry, Mathematical Cell Biology, and Quantitative Biochemistry)

Regulatory Networks

Entering the Living Cell

Tumor Cell Biology

Cell & Environment

Relevant collaborations (e.g.):

- National:

· Peletier, Blom, van Schuppen (CWI)

· Kaandorp (UvA)